Petroquinones: trimeric and dimeric xestoquinone derivatives isolated from the marine sponge Petrosia alfiani
- 田之頭 夏希
- Kukita Sanako
- 加藤 光
- Nehira Tatsuo
- Angkouw Esther D.
- Mangindaan Remy E.P.
- de Voogd Nicole J.
- 塚本 佐知子
- Natsuki Tanokashira
- Sanako Kukita
- Hikaru Kato
- Tetsuo Nehira
- Esther D. Angkouw
- Remy E.P. Mangindaan
- Nicole J. de Voogd
- Sachiko Tsukamoto
DOIAbstract
We isolated 16 new xestoquinone derivatives, including two trimers, six dimers, and four monomers with containing thiomorpholine 1,1-dioxide and pyrrolidine-2,4-diol moieties, from the marine sponge Petrosia alfiani and determined their structures including the absolute configurations using computational methods. They exhibited potent inhibitory activities against USP7 with IC50 values in the range of 0.13–2.0 μ
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