Reperfusion injury and the effect of leukocyte depletion on a storage lung -Comparison of UW solution and Euro-Collins solution-

Using isolated perfusion model of a donor lung preserved for 24 hours, the efficacy of UW solution in lung preservation was evaluated in comparison with Euro-Collins (E-C) solution as well as the inhibitory effect of leukocyte depletion on post ischemic reperfusion injury. The following results were obtained. 1) After 24 hours of preservation, the lung functions were maintained more favorably in UW solution when compared with the results obtained with E-C solution, indicating that UW solution the best for a long-term preservation of a donor lung 2) By depleting leukocytes at the time of reperfusion, it was possible to minimize the reperfusion injury. 3) The model used in the present study was available for simple and useful means of evaluating the validity of lung preservation solution and the intensity of reperfusion injury