Anti-glycyl tRNA synthetase antibody associated interstitial lung disease without symptoms of polymyositis/dermatomyositis

Anti-Glycyl tRNA synthetase (EJ) autoantibody is a form of eight anti-aminoacyl tRNA synthetase (ARS) antibodies which frequently associate with polymyositis (PM) and dermatomyositis (DM). Interstitial lung disease (ILD) rarely is an only disease among those patients in which patients with anti-EJ antibody are fairly common, however, their pathological features have never been described. Here, we report a case of anti-EJ antibody associated ILD without symptoms of PM/DM. A 56 year-old woman presented rapidly progressing dyspnea. Her radiograph showed ILD and wedge lung biopsy was taken for pathological diagnosis. The biopsy showed cellular and fibrotic ILD best fitting to non-specific interstitial pneumonia along with the features of acute lung injury. The patient was treated with high dose methylprednisolone followed by combination of prednisolone and cyclosporine, which showed good response