Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
- Lin, Wei Yu
- Fordham, Sarah E.
- Hungate, Eric
- Sunter, Nicola J.
- Elstob, Claire
- Xu, Yaobo
- Park, Catherine
- Quante, Anne
- Strauch, Konstantin
- Gieger, Christian
- Skol, Andrew
- Rahman, Thahira
- Sucheston-Campbell, Lara
- Wang, Junke
- Hahn, Theresa
- Clay-Gilmour, Alyssa I.
- Jones, Gail L.
- Marr, Helen J.
- Jackson, Graham H.
- Menne, Tobias
- Collin, Mathew
- Ivey, Adam
- Hills, Robert K.
- Burnett, Alan K.
- Russell, Nigel H.
- Fitzgibbon, Jude
- Larson, Richard A.
- Le Beau, Michelle M.
- Stock, Wendy
- Heidenreich, Olaf
- Alharbi, Abrar
- Allsup, David J.
- Houlston, Richard S.
- Norden, Jean
- Dickinson, Anne M.
- Douglas, Elisabeth
- Lendrem, Clare
- Daly, Ann K.
- Palm, Louise
- Piechocki, Kim
- Jeffries, Sally
- Bornhäuser, Martin
- Röllig, Christoph
- Altmann, Heidi
- Ruhnke, Leo
- Kunadt, Desiree
- Wagenführ, Lisa
- Cordell, Heather J.
- Darlay, Rebecca
- Andersen, Mette K.
- Fontana, Maria C.
- Martinelli, Giovanni
- Marconi, Giovani
- Sanz, Miguel A.
- Cervera, José
- Gómez-Seguí, Inés
- Cluzeau, Thomas
- Moreilhon, Chimène
- Raynaud, Sophie
- Sill, Heinz
- Voso, Maria Teresa
- Lo-Coco, Francesco
- Dombret, Hervé
- Cheok, Meyling
- Preudhomme, Claude
- Gale, Rosemary E.
- Linch, David
- Gaal-Wesinger, Julia
- Masszi, Andras
- Nowak, Daniel
- Hofmann, Wolf Karsten
- Gilkes, Amanda
- Porkka, Kimmo
- Milosevic Feenstra, Jelena D.
- Kralovics, Robert
- Grimwade, David
- Meggendorfer, Manja
- Haferlach, Torsten
- Krizsán, Szilvia
- Bödör, Csaba
- Stölzel, Friedrich
- Onel, Kenan
- Allan, James M.
DOIAbstract
Publisher Copyright: © 2021, The Author(s).Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 x 10(-8); KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 x 10(-10); HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA). Genome wide association studies in c...
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