The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery

Scope: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. Methods and Results: Databases were systematically searched from March 2019 up to May 2020 resulting in 4062 articles, of which 45 were retr