Blood Glucose Changes between Preoperative Administration of Sorbitol 25Gram / 500ml (Tutofusin®) and Lactated Ringer in Patient Undergoing Elective Surgery

Background: Perioperative blood glucose control affects intraoperative and postoperative morbidity and mortality. Stress response often associated with increase glucagon secretion and insulin resistance causing hyperglycemia. The combination of tissue injury, fasting, bleeding, anesthetic medications and low temperature lead to increased stress responses. Objective: This study aims to compare the changes in postoperative plasma blood glucose between preoperative administration of sorbitol 25 gram / 500 ml (Tutofusin®) and Lactated Ringer (LR) in elective surgery patient. Methods: A total of 66 patients were randomized to one of the following groups: S group received 500 ml intravenous fluid containing sorbitol 25 gram (Tutofusin 500cc); LR group received 500 ml of lactated ringer solution, both were given preoperatively while on fasting period. Blood glucose was measured preoperatively, before induction of anesthesia, and postoperative once the patient arrive at the recovery room. Results: There were no significant differences in the blood glucose values at preoperative and prior to induction of anesthesia. Postoperatively, sorbitol group had significance lower blood glucose level compared to LR group (P= 0.006). Furthermore, preoperative sorbitol administration decreased blood glucose level while LR administration post-operative increased blood glucose level (P= 0.024). Conclusion : Preoperative administration of Sorbitol 25 gram / 500 ml (Tutofusin®) did not increase postoperative plasma glucose level compared with Lactated-Ringer solution