Mesenchymal Stem Cell Injection in Two Patients Suffer From Chronic Discogenic Low Back Pain

Background: Discogenic low back pain is one of the leading causes of pain and disability across the world. A growing interest in the area of regenerative medicine, led by an improved understanding of the role of mesenchymal stem cells in tissue homeostasis and repair.Cases Report: We had two patients suffered from chronic discogenic low back pain. They were underwent injection of intra-discal 1.5 cc of Adipose Derived Mesenchymal Stem Cells (ADMSC) and followed up for 6 months. After this period of time, there was a significant reduction in both VAS and ODI scores in patients.Conclusion: These data warrant further studies so that we can enhance our understanding of the other unknown mechanisms, which may exist behind stem cell injection. If the effectiveness of such injection to reduce pain and improve function is shown in the upcoming studies, it may provide a new insight for increasing this method of treatment as a proper option in the near future