Altered Aortic Hemodynamics and Relative Pressure in Patients with Dilated Cardiomyopathy

Abstract Ventricular-vascular interaction is central in the adaptation to cardiovascular disease. However, cardiomyopathy patients are predominantly monitored using cardiac biomarkers. The aim of this study is therefore to explore aortic function in dilated cardiomyopathy (DCM). Fourteen idiopathic DCM patients and 16 controls underwent cardiac magnetic resonance imaging, with aortic relative pressure derived using physics-based image processing and a virtual cohort utilized to assess the impact of cardiovascular properties on aortic behaviour. Subjects with reduced left ventricular systolic function had significantly reduced aortic relative pressure, increased aortic stiffness, and significantly delayed time-to-pressure peak duration. From the virtual cohort, aortic stiffness and aortic volumetric size were identified as key determinants of aortic relative pressure. As such, this study shows how advanced flow imaging and aortic hemodynamic evaluation could provide novel insights into the manifestation of DCM, with signs of both altered aortic structure and function derived in DCM using our proposed imaging protocol. Graphic AbstractrBritish Heart Foundation. New Horizons Program (NH/11/5/29058)Engineering and Physical Sciences Research Council (EP/H046410/1 and EP/N011554/1)Guy's & St. Thomas' NHS Foundation TrustEngineering and Physical Sciences Research Council. Wellcome Trust-EPSRC Centre of Excellence in Medical Engineering ((WT 088641/Z/09/Z)National Institute for Healthcare Research. Cardiovascular MedTech CooperativeMarcus Wallenberg Foundation for International Cooperation in Scienc