Translational errors frequently arise during protein synthesis, producing misfolded and dysfunctional proteins. Chronic stress resulting from translation errors may be particularly relevant in tissues that must synthesize and secrete large amounts of secretory proteins. Here, we studied the proteostasis networks in the liver of mice that express the Rps2-A226Y ribosomal ambiguity (ram) mutation to increase the translation error rate across all proteins. We found that Rps2-A226Y mice lack activation of the eIF2 kinase/ATF4 pathway, the main component of the integrated stress response (ISR), as well as the IRE1 and ATF6 pathways of the ER unfolded protein response (ER-UPR). Instead, we found downregulation of chronic ER stress responses, as i...
Background: The unfolded protein response (UPR) refers to intracellular stress signaling pathways th...
In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurkat, by sc...
All living organisms must adapt to their ever-changing environment in order to maintain homeostasis ...
Translational errors frequently arise during protein synthesis, producing misfolded and dysfunctiona...
SummaryThe unfolded protein response (UPR) is linked to metabolic dysfunction, yet it is not known h...
Numerous studies linked endoplasmic reticulum (ER) stress and unfolded protein response (UPR) to phy...
Proteostasis is essential for cellular survival and particularly important for highly specialised po...
SummaryThe ER's capacity to process proteins is limited, and stress caused by accumulation of unfold...
© 2019, The Author(s). The UPR (Unfolded Protein Response) is a well-orchestrated response to ER pro...
poster abstractDisruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER s...
SummaryThe unfolded protein response (UPR) is a stress response program that reprograms cellular tra...
<div><p>In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurka...
Endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR) have bee...
The presence of endoplasmic reticulum (ER) stress and impaired ubiquitin–proteasome system (UPS) act...
In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurkat, by sc...
Background: The unfolded protein response (UPR) refers to intracellular stress signaling pathways th...
In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurkat, by sc...
All living organisms must adapt to their ever-changing environment in order to maintain homeostasis ...
Translational errors frequently arise during protein synthesis, producing misfolded and dysfunctiona...
SummaryThe unfolded protein response (UPR) is linked to metabolic dysfunction, yet it is not known h...
Numerous studies linked endoplasmic reticulum (ER) stress and unfolded protein response (UPR) to phy...
Proteostasis is essential for cellular survival and particularly important for highly specialised po...
SummaryThe ER's capacity to process proteins is limited, and stress caused by accumulation of unfold...
© 2019, The Author(s). The UPR (Unfolded Protein Response) is a well-orchestrated response to ER pro...
poster abstractDisruptions of the endoplasmic reticulum (ER) that perturb protein folding cause ER s...
SummaryThe unfolded protein response (UPR) is a stress response program that reprograms cellular tra...
<div><p>In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurka...
Endoplasmic reticulum (ER) stress and the activation of the unfolded protein response (UPR) have bee...
The presence of endoplasmic reticulum (ER) stress and impaired ubiquitin–proteasome system (UPS) act...
In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurkat, by sc...
Background: The unfolded protein response (UPR) refers to intracellular stress signaling pathways th...
In this work we have described the translatome of two mammalian cell lines, NIH3T3 and Jurkat, by sc...
All living organisms must adapt to their ever-changing environment in order to maintain homeostasis ...