ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives
- von Loeffelholz, Christian
- Pfeiffer, Andreas F H
- Lock, Johan F
- Lieske, Steffi
- Döcke, Stephanie
- Murahovschi, Veronica
- Kriebel, Jennifer
- de Las Heras Gala, Tonia
- Grallert, Harald
- Rudovich, Natalia
- Stockmann, Martin
- Spranger, Joachim
- Jahreis, Gerhard
- Bornstein, Stefan R
- Lau, George
- Xu, Aimin
- Schulz-Menger, Jeanette
- Exner, Louisa
- Haufe, Sven
- Jordan, Jens
- Engeli, Stefan
- Birkenfeld, Andreas L
DOIAbstract
Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated.Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutane...
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