Autonomic cardiac regulation during spontaneous nocturnal hypoglycemia in children with type 1 diabetes
- Bachmann, Sara
- Auderset, Anne
- Burckhardt, Marie-Anne
- Szinnai, Gabor
- Hess, Melanie
- Zumsteg, Urs
- Denhaerynck, Kris
- Donner, Birgit
DOIAbstract
Hypoglycemia is the most common complication in insulin treated diabetes. Though mostly mild, it can be fatal in rare cases: It is hypothesized that hypoglycemia related QTc prolongation contributes to cardiac arrhythmia.; To evaluate influence of nocturnal hypoglycemia on QTc and heart rate variability (HRV) in children with T1D.; Children and adolescents with T1D for at least 6 months participated in an observational study using continuous glucose monitoring (CGM) and Holter electrocardiogram for five consecutive nights. Mean QTc was calculated for episodes of nocturnal hypoglycemia (<3.7 mmol/L) and compared to periods of the same duration preceding hypoglycemia. HRV (RMSSD, low and high frequency power LF and HF) was analyzed for differ...
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