Multiantenna signal processing (MASP) is indispensable in many applications like wireless communications, radar, seismology, etc. Large-scale antenna arrays (LSAAs) are envisioned for future wireless communication systems to improve the range, power, and spectral efficiency (SE) of existing systems. Thus, for a practical multiantenna wireless communication system, efficient and scalable signal processing (SP) algorithms are essential to optimize system operations. In this thesis, we address several facets of such system optimization including beampattern matching, SE maximization among others. These are formulated as nonconvex optimization problems and the thesis proposes novel, efficient, and scalable optimization algorithms with theoretic...