Motor function changes in three genotypes of mice exposed to benzo[a]pyrene during gestation and lactation

2021 Celebration of Student Research and Creativity presentation"Benzo[a]pyrene (BaP) is a known carcinogen found in automobile exhaust, wood fire smoke, tobacco smoke, grilled food and coal tar. Many studies found exposure to these pollutants during pregnancy can damage genes and the placenta and impair fetal growth. We use mice that mimic human genetic variation in genes related to BaP metabolism to identify those at highest risk. In this study, we looked at motor function in adult mice exposed to BaP during gestation and lactation. We found no effect of genotype, but discovered Cyp1a2 knockout mice have deficits in motor coordination on the rotarod test."https://youtu.be/C-d9P__2qv