BACKGROUND: p53 is a transcription factor that regulates the cell cycle, DNA repair, and apoptosis. A variant at codon 72, rs1042522, results in altered activities for p53 and is, notably, differentially distributed among different ethnic populations. However, associations of this variant with cancer in men of African descent have not been explored. Herein, we tested the hypothesis that rs1042522 was associated with prostate cancer (PCa) risk. MATERIALS AND METHODS: Genotypes were determined by PCR-RFLP methods in a study population of African descent consisting of 266 PCa patients and 196 male controls. RESULTS: Our results indicate that the p53 polymorphism may be associated with increased risk of PCa. Genotypes were significantly and mar...
Prostate cancer (PCa) is a complex disease that disproportionately affects African Americans and oth...
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The ris...
The tumor suppressor gene p53 plays an important role in the stress response of the cell and is muta...
BACKGROUND: p53 is a transcription factor that regulates the cell cycle, DNA repair, and apoptosis. ...
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The ris...
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The ris...
BACKGROUND: Genetic factors play an important role in prostate cancer (PCa) susceptibility. OBJECTIV...
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate ca...
International audienceAlthough men of African ancestry have a high risk of prostate cancer (PCa), no...
Genome-wide association studies have identified more than 80 risk variants for prostate cancer, main...
In search of common risk alleles for prostate cancer that could contribute to high rates of the dise...
BACKGROUND:Estrogens are thought to play a critical role in prostate carcinogenesis. It has been sug...
[[abstract]]The tumor suppressor gene p53 and its downstream effector p21 are thought to play major ...
Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still li...
International audienceBACKGROUND: Estrogens are thought to play a critical role in prostate carcinog...
Prostate cancer (PCa) is a complex disease that disproportionately affects African Americans and oth...
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The ris...
The tumor suppressor gene p53 plays an important role in the stress response of the cell and is muta...
BACKGROUND: p53 is a transcription factor that regulates the cell cycle, DNA repair, and apoptosis. ...
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The ris...
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The ris...
BACKGROUND: Genetic factors play an important role in prostate cancer (PCa) susceptibility. OBJECTIV...
The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate ca...
International audienceAlthough men of African ancestry have a high risk of prostate cancer (PCa), no...
Genome-wide association studies have identified more than 80 risk variants for prostate cancer, main...
In search of common risk alleles for prostate cancer that could contribute to high rates of the dise...
BACKGROUND:Estrogens are thought to play a critical role in prostate carcinogenesis. It has been sug...
[[abstract]]The tumor suppressor gene p53 and its downstream effector p21 are thought to play major ...
Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still li...
International audienceBACKGROUND: Estrogens are thought to play a critical role in prostate carcinog...
Prostate cancer (PCa) is a complex disease that disproportionately affects African Americans and oth...
Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The ris...
The tumor suppressor gene p53 plays an important role in the stress response of the cell and is muta...