Summary. Recent studies suggest that nitric oxide (NO) may partly be responsible for the beneficial effect of hydroxyurea (HU) in sickle cell disease (SCD) patients. NO stimulates cyclic guanosine monophosphate (cGMP) production, which mediates vasodilatation. We investigated the association between NO, cGMP and fetal haemoglobin (HbF) levels after HU administration. Our data showed that chronic HU significantly increased NO, cGMP, and HbF levels in SCD. Recently it was shown that HbF production was stimulated by cGMP-dependent protein kinase. Our results suggest that NO stimulates cGMP production, which then activates a protein kinase and increases the production of HbF
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Neutrophilia is a feature of sickle cell disease (SCD) that has been consistently correlated with cl...
Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical seve...
Summary. Recent studies suggest that nitric oxide (NO) may partly be responsible for the beneficial ...
Activation of soluble guanylate cyclase (sGC) has been reported to up-regulate gamma-globin gene tra...
International audienceHydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sic...
Induction of fetal hemoglobin (Hb F) is an important therapeutic tool in ameliorating complications ...
The clinical efficacy of hydroxyurea (HU) in the treatment of sickle cell anemia has mainly been att...
Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis...
Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis...
Objectives: Fetal hemoglobin (HbF) induction involves NO-cGMP signaling pathways. l-arginine, an NO ...
Hydroxyurea (HU) causes nitric oxide (NO) bioactivation, acting as both a NO donor and a stimulator ...
Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in sickle cell di...
Sickle cell disease (SCD) is an inherited disease caused by the production of abnormal hemoglobin (H...
Hydroxyurea (HU), the first of two drugs approved by the US Food and Drug Administration for treatin...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Neutrophilia is a feature of sickle cell disease (SCD) that has been consistently correlated with cl...
Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical seve...
Summary. Recent studies suggest that nitric oxide (NO) may partly be responsible for the beneficial ...
Activation of soluble guanylate cyclase (sGC) has been reported to up-regulate gamma-globin gene tra...
International audienceHydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sic...
Induction of fetal hemoglobin (Hb F) is an important therapeutic tool in ameliorating complications ...
The clinical efficacy of hydroxyurea (HU) in the treatment of sickle cell anemia has mainly been att...
Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis...
Hydroxyurea is used for sickle-cell disease patients in order to increase fetal hemoglobin synthesis...
Objectives: Fetal hemoglobin (HbF) induction involves NO-cGMP signaling pathways. l-arginine, an NO ...
Hydroxyurea (HU) causes nitric oxide (NO) bioactivation, acting as both a NO donor and a stimulator ...
Increased leukocyte adhesion to vascular endothelium contributes to vaso-occlusion in sickle cell di...
Sickle cell disease (SCD) is an inherited disease caused by the production of abnormal hemoglobin (H...
Hydroxyurea (HU), the first of two drugs approved by the US Food and Drug Administration for treatin...
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Ci...
Neutrophilia is a feature of sickle cell disease (SCD) that has been consistently correlated with cl...
Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical seve...