Add to ORKGBackground and purpose: HIV-1 transcription is activated by the Tat protein which recruits the cyclin-dependent kinase CDK9/cyclin T1 to TAR RNA. Tat binds to protein phosphatase-1 (PP1) through the Q35VCF38 sequence and translocates PP1 to the nucleus. PP1 dephosphorylates CDK9 and activates HIV-1 transcription. We have synthesized a low MW compound 1H4, that targets PP1 and prevents HIV-1 Tat interaction with PP1 and inhibits HIV-1 gene transcription. Here, we report our further work with the 1H4-derived compounds and analysis of their mechanism of action
<p>A. The model of 1H4 interaction with PP1. 1H4 occupies hydrophobic sites of Phe68’ and Val 66′ si...
BACKGROUND: HIV-1 escapes antiretroviral drugs by integrating into the host DNA and forming a latent...
Background: HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consis...
Background and purpose: HIV-1 transcription is activated by the Tat protein which recruits the cycli...
HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby i...
The emergence of drug-resistant HIV-1 strains presents a challenge for the design of new drugs. Targ...
<div><p>HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and t...
HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby i...
Transcription of human immunodeficiency virus (HIV)-1 genes is activated by HIV-1 Tat protein, which...
Background: HIV-1 escapes antiretroviral drugs by integrating into the host DNA and forming a latent...
CDK9/cyclin T1, a key enzyme in HIV-1 transcription, is negatively regulated by 7SK RNA and the HEXI...
The HIV-1 Tat protein interacts with TAR RNA and recruits CDK9/cyclin T1 and other host factors to i...
We recently identified the protein phosphatase-1-targeting compound, 1E7-03 which inhibited HIV-1 in...
After entry into the target cell, the human immunodeficiency virus type I (HIV) integrates into the ...
Combination antiretroviral therapy (cART) suppresses human immunodeficiency virus-1 (HIV-1) replicat...
<p>A. The model of 1H4 interaction with PP1. 1H4 occupies hydrophobic sites of Phe68’ and Val 66′ si...
BACKGROUND: HIV-1 escapes antiretroviral drugs by integrating into the host DNA and forming a latent...
Background: HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consis...
Background and purpose: HIV-1 transcription is activated by the Tat protein which recruits the cycli...
HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby i...
The emergence of drug-resistant HIV-1 strains presents a challenge for the design of new drugs. Targ...
<div><p>HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and t...
HIV-1 Tat protein recruits host cell factors including CDK9/cyclin T1 to HIV-1 TAR RNA and thereby i...
Transcription of human immunodeficiency virus (HIV)-1 genes is activated by HIV-1 Tat protein, which...
Background: HIV-1 escapes antiretroviral drugs by integrating into the host DNA and forming a latent...
CDK9/cyclin T1, a key enzyme in HIV-1 transcription, is negatively regulated by 7SK RNA and the HEXI...
The HIV-1 Tat protein interacts with TAR RNA and recruits CDK9/cyclin T1 and other host factors to i...
We recently identified the protein phosphatase-1-targeting compound, 1E7-03 which inhibited HIV-1 in...
After entry into the target cell, the human immunodeficiency virus type I (HIV) integrates into the ...
Combination antiretroviral therapy (cART) suppresses human immunodeficiency virus-1 (HIV-1) replicat...
<p>A. The model of 1H4 interaction with PP1. 1H4 occupies hydrophobic sites of Phe68’ and Val 66′ si...
BACKGROUND: HIV-1 escapes antiretroviral drugs by integrating into the host DNA and forming a latent...
Background: HIV-1 Tat protein recruits human positive transcription elongation factor P-TEFb, consis...
