The role of nitric oxide in the efficacy of adenosine, lidocaine and magnesium (ALM) treatment of experimental hemorrhagic shock in rats
- Letson, Hayley L.
- Dobson, Geoffrey P.
DOIAbstract
Background: Since nitric oxide (NO) plays multiple roles regulating the central nervous, cardiovascular and immune systems, our aim was to investigate the role of NO in the efficacy of 7.5% NaCl adenosine, lidocaine and magnesium (ALM) to improve mean arterial pressure (MAP) and heart rate (HR) following hemorrhagic shock (HS). Methods: Male Sprague-Dawley rats (101; 425±6g) were randomly assigned to 20 groups (n=4-n=8). HS (MAP<40mmHg) was induced by 20min pressure-controlled bleeding (∼40% blood volume), and the animal was left in shock (MAP 35-40mmHg) for 60min. NO synthase (NOS) inhibitor L-NAME was administered with a 0.3ml bolus of different combinations of 7.5% NaCl ALM active ingredients and hemodynamics were monitored for 60mi...
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