Decades have passed without approval of a new antibiotic class. Several companies have recently halted related discovery efforts because of multiple obstacles. One promising route under research is to target the lipoprotein maturation pathway in light of major recent findings and the virulence roles of lipoproteins. To support the future design of selective drugs, considerations and priority-setting are established for the main lipoprotein processing enzymes (Lgt, LspA, and Lnt) based on microbiology, biochemistry, structural biology, chemical design, and pharmacology. Although not all bacterial species will be similarly impacted by drug candidates, several advantages make LspA a top target to pursue in the development of novel antibiotics ...
Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of a...
Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of a...
NoGram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral ...
Lipoproteins have key functions in many bacteria. They are synthesized in a precursor form that requ...
The standard and most successful treatment for bacterial infections is antibiotic therapy, with drug...
Antimicrobial resistance has drawn more and more attention from the world public health community an...
Lipopolysaccharides (LPSs), which constitute the lipid portion of the outer leaflet of Gram-negative...
Lipoproteins serve essential roles in the bacterial cell envelope. The posttranslational modificatio...
We are entering an era where the efficacy of current antibiotics is declining, due to the developmen...
WGS data have been submitted to the NCBI SRA database under accession number PRJNA860548.Internation...
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to conti...
Antibiotic resistance has been an emerging threat to the public health. Since the discovery of penic...
Lipopolysaccharide (LPS), which constitutes the lipid portion of the outer leaflet of Gram-negative ...
International audienceLipoproteins are characterized by a fatty acid moiety at their amino‐terminus ...
SummaryThe lipopolysaccharide (LPS)-rich outer membrane of gram-negative bacteria provides a protect...
Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of a...
Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of a...
NoGram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral ...
Lipoproteins have key functions in many bacteria. They are synthesized in a precursor form that requ...
The standard and most successful treatment for bacterial infections is antibiotic therapy, with drug...
Antimicrobial resistance has drawn more and more attention from the world public health community an...
Lipopolysaccharides (LPSs), which constitute the lipid portion of the outer leaflet of Gram-negative...
Lipoproteins serve essential roles in the bacterial cell envelope. The posttranslational modificatio...
We are entering an era where the efficacy of current antibiotics is declining, due to the developmen...
WGS data have been submitted to the NCBI SRA database under accession number PRJNA860548.Internation...
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to conti...
Antibiotic resistance has been an emerging threat to the public health. Since the discovery of penic...
Lipopolysaccharide (LPS), which constitutes the lipid portion of the outer leaflet of Gram-negative ...
International audienceLipoproteins are characterized by a fatty acid moiety at their amino‐terminus ...
SummaryThe lipopolysaccharide (LPS)-rich outer membrane of gram-negative bacteria provides a protect...
Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of a...
Research into antibacterial agents has recently gathered pace in light of the disturbing crisis of a...
NoGram-positive bacterial lipoproteins are a functionally diverse and important class of peripheral ...
.jpg%3Fwidth%3D300&w=3840&q=75)
_and_Carl_Ferdinand_Cori_-_restoration1.jpg%3Fwidth%3D300&w=3840&q=75)
Add to ORKG