HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor immunogens in general, however rare HIV neutralizing antibodies nevertheless potently recognize the glycan epitopes. While CD4 and chemokine receptors have been known as viral entry receptor and coreceptor, for many years the role of viral glycans in HIV entry was controversial. Recently, we showed that HIV envelope glycan binds to L-selectin in solution and on CD4 T lymphocytes. The viral glycan and L-selectin interaction functions to facilitate the viral adhesion and entry. Upon entry, infected CD4 T lymp...
Leukocyte recirculation between blood and lymphoid tissues is required for the generation andmainten...
Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low ...
BackgroundCarbohydrate-binding agents (CBAs) are potent antiretroviral compounds that target the N-g...
The natural function of dendritic cells (DCs) is to capture and degrade pathogens for Ag presentatio...
AbstractWe demonstrate that human immunodeficiency virus HIV-1LAI envelope glycoprotein 120 (gp120LA...
Sexual transmission of HIV-1 requires virus adsorption to a target cell, typically a CD4 T lymphocy...
Background: Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite rel...
Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low ...
Infection by human immunodeficiency virus type 1 (HIV-1) is a multi-step process, and detailed analy...
Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the etiological agents of AIDS in h...
The human immunodeficiency virus type 1 (HIV-1) utilizes multiple cell surface molecules to mediate ...
International audienceBy targeting cells that provide protection against infection, HIV-1 causes acq...
Leukocytes recirculation between blood and lymphoid tissues is required for the generation and maint...
AbstractIt is generally believed that during the sexual transmission of HIV-1, the glycan-specific D...
The HIV-1 envelope glycoprotein (Env) is the sole target for HIV broadly neutralizing antibodies (bn...
Leukocyte recirculation between blood and lymphoid tissues is required for the generation andmainten...
Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low ...
BackgroundCarbohydrate-binding agents (CBAs) are potent antiretroviral compounds that target the N-g...
The natural function of dendritic cells (DCs) is to capture and degrade pathogens for Ag presentatio...
AbstractWe demonstrate that human immunodeficiency virus HIV-1LAI envelope glycoprotein 120 (gp120LA...
Sexual transmission of HIV-1 requires virus adsorption to a target cell, typically a CD4 T lymphocy...
Background: Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite rel...
Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low ...
Infection by human immunodeficiency virus type 1 (HIV-1) is a multi-step process, and detailed analy...
Human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) are the etiological agents of AIDS in h...
The human immunodeficiency virus type 1 (HIV-1) utilizes multiple cell surface molecules to mediate ...
International audienceBy targeting cells that provide protection against infection, HIV-1 causes acq...
Leukocytes recirculation between blood and lymphoid tissues is required for the generation and maint...
AbstractIt is generally believed that during the sexual transmission of HIV-1, the glycan-specific D...
The HIV-1 envelope glycoprotein (Env) is the sole target for HIV broadly neutralizing antibodies (bn...
Leukocyte recirculation between blood and lymphoid tissues is required for the generation andmainten...
Human immunodeficiency virus type 1 (HIV-1) infects macrophages effectively, despite relatively low ...
BackgroundCarbohydrate-binding agents (CBAs) are potent antiretroviral compounds that target the N-g...