Lionfish have highly toxic venom and envenomation may result in a wide spectrum of complaints in humans ranging from sharp pain to infection and necrosis of the soft tissue. Symptoms of lionfish envenomation include sharp pain, swelling, redness, bleeding, nausea, numbness, anxiety, joint pain, headache, dizziness, and even anaphylactic reaction resulting in death. Treatment involves applying immersion of the affected area in hot water at 42-45 0C for 30-90 min, analgesics, tetanus toxoid, and antibiotics. Complications such as soft tissue infection, bone-joint infection, and even tissue necrosis may appear due to the tissue damage of unnoticed fish spines or other foreign bodies. A 36-year-old male patient was admitted to the hospital with...