Phytochemicals: Do they belong on our plate for sustaining healthspan?

Abstract That phytochemicals are a critical part of enhancing healthspan is in our minds a linchpin of responsible public health messaging, yet, recent dietary guidelines and strategies for implementing precision nutrition largely ignore roles of phytochemicals. Epidemiological evidence points strongly to beneficial effects of phytochemical‐rich foods on the prevention of essentially all chronic diseases. An extraordinary multitude of phytochemicals have been shown in preclinical settings to be potent allies in our fight against the entire spectrum of chronic diseases and many acute conditions such as infections. Yet unequivocal proof of this concept is problematic due to the nature of the clinical trials that must be part of such a proof. More rigor in the design and implementation of such trials is essential. Artificial intelligence, machine learning, metabolomics, microbiomics, proteomics, and other high‐powered data processing modalities, may inform the phyto‐dynamic actions on very specific metabolic pathways. As phytochemical abundance appears to be declining in our food supply, the need for better and more strategically focused science is great