International audienceNext-generation sequencing technology is enabling massive production of high-quality paired-end reads. Many platforms (Illumina Genome Analyzer, Applied Biosystems SOLID, Helicos HeliScope) are currently able to produce "ultra-short" paired reads of lengths starting at 25 nt. An analysis by Whiteford et al. [1] on sequencing using unpaired reads shows that ultra-short reads theoretically allow whole genome re-sequencing and de novo assembly of only small eukaryotic genomes. By conducting an analysis extending Whiteford et al. results, we investigate to what extent genome re-sequencing is feasible with ultra-short paired reads. We obtain theoretical read length lower bounds for re-sequencing that are also applicable to ...
Motivation: Paired-end sequencing allows circumventing the shortness of the reads produced by second...
Background: Recent studies on genome assembly from short-read sequencing data reported the limitatio...
Background: De Bruijn graphs are a theoretical framework underlying several modern genome assembly p...
International audienceNext-generation sequencing technology is enabling massive production of high-q...
International audienceNext-generation sequencing technology is enabling massive production of high-q...
International audienceNext-generation sequencing technology is enabling massive production of high-q...
Several methods for ultra high-throughput DNA sequencing are currently under investigation. Many of ...
Several methods for ultra high-throughput DNA sequencing are currently under investigation. Many of ...
Several methods for ultra high-throughput DNA sequencing are currently under investigation. Many of ...
[[abstract]]Background: Recent studies on genome assembly from short-read sequencing data reported t...
<div><p>Background</p><p>Recent studies on genome assembly from short-read sequencing data reported ...
Background: Next-generation sequencing technologies allow genomes to be sequenced more quickly and l...
Novel sequencing technologies permit the rapid production of large sequence data sets. These technol...
Novel sequencing technologies permit the rapid production of large sequence data sets. These technol...
Novel sequencing technologies permit the rapid production of large sequence data sets. These technol...
Motivation: Paired-end sequencing allows circumventing the shortness of the reads produced by second...
Background: Recent studies on genome assembly from short-read sequencing data reported the limitatio...
Background: De Bruijn graphs are a theoretical framework underlying several modern genome assembly p...
International audienceNext-generation sequencing technology is enabling massive production of high-q...
International audienceNext-generation sequencing technology is enabling massive production of high-q...
International audienceNext-generation sequencing technology is enabling massive production of high-q...
Several methods for ultra high-throughput DNA sequencing are currently under investigation. Many of ...
Several methods for ultra high-throughput DNA sequencing are currently under investigation. Many of ...
Several methods for ultra high-throughput DNA sequencing are currently under investigation. Many of ...
[[abstract]]Background: Recent studies on genome assembly from short-read sequencing data reported t...
<div><p>Background</p><p>Recent studies on genome assembly from short-read sequencing data reported ...
Background: Next-generation sequencing technologies allow genomes to be sequenced more quickly and l...
Novel sequencing technologies permit the rapid production of large sequence data sets. These technol...
Novel sequencing technologies permit the rapid production of large sequence data sets. These technol...
Novel sequencing technologies permit the rapid production of large sequence data sets. These technol...
Motivation: Paired-end sequencing allows circumventing the shortness of the reads produced by second...
Background: Recent studies on genome assembly from short-read sequencing data reported the limitatio...
Background: De Bruijn graphs are a theoretical framework underlying several modern genome assembly p...