Maternal diet is critical for offspring development and long-term health. Here we investigated the effects of a poor maternal diet pre-conception and during pregnancy on metabolic outcomes and the developing hypothalamus in male and female offspring at birth. We hypothesised that offspring born to dams fed a diet high in fat and sugar (HFSD) peri-pregnancy will have disrupted metabolic outcomes. We also determined if these HFSD-related effects could be reversed by a shift to a healthier diet post-conception, in particular to a diet high in omega-3 polyunsaturated fatty acids (ω3 PUFAs), since ω3 PUFAs are considered essential for normal neurodevelopment. Unexpectedly, our data show that there are minimal negative effects of mate...
Diet of mothers during gestation may impact offspring phenotype. This study evaluated the consequenc...
UNLABELLED: Restriction of protein or energy intake during gestation or early life is linked to deve...
Supplementary Materials: The following are available online at http://www.mdpi.com/2072-6643/11/1/96...
Nutritional factors during a sensitive perinatal period may lead to developmental adaptations propos...
BACKGROUND: Metabolic and endocrine environment during early life is crucial for metabolic imprintin...
We have previously reported that offspring of mothers fed a high fat (HF) diet during pregnancy and ...
Metabolic and endocrine environment during early life is crucial for metabol...
Lipid molecules are the building blocks of all cell membranes and provide essential secondary metabo...
Maternal factors can have major imprinting effects on homeostatic mechanisms in the developing fetus...
Failure to provide omega 3 fatty acids in the perinatal period results in alterations in nerve growt...
Maternal high-fat (HF) diet throughout gestation and suckling has long-term consequences on the offs...
OBJECTIVE - To investigate the effect of maternal dietary omega-3 polyunsaturated fatty acid (PUFA) ...
The increasing prevalence of obesity and its effects on our society warrant intensifying basic anima...
Early stress can cause metabolic disorders in adulthood. Omega-3 polyunsaturated fatty acids (n-3 PU...
Gestational obesity has major negative impacts on both mothers and their offspring. More than two-th...
Diet of mothers during gestation may impact offspring phenotype. This study evaluated the consequenc...
UNLABELLED: Restriction of protein or energy intake during gestation or early life is linked to deve...
Supplementary Materials: The following are available online at http://www.mdpi.com/2072-6643/11/1/96...
Nutritional factors during a sensitive perinatal period may lead to developmental adaptations propos...
BACKGROUND: Metabolic and endocrine environment during early life is crucial for metabolic imprintin...
We have previously reported that offspring of mothers fed a high fat (HF) diet during pregnancy and ...
Metabolic and endocrine environment during early life is crucial for metabol...
Lipid molecules are the building blocks of all cell membranes and provide essential secondary metabo...
Maternal factors can have major imprinting effects on homeostatic mechanisms in the developing fetus...
Failure to provide omega 3 fatty acids in the perinatal period results in alterations in nerve growt...
Maternal high-fat (HF) diet throughout gestation and suckling has long-term consequences on the offs...
OBJECTIVE - To investigate the effect of maternal dietary omega-3 polyunsaturated fatty acid (PUFA) ...
The increasing prevalence of obesity and its effects on our society warrant intensifying basic anima...
Early stress can cause metabolic disorders in adulthood. Omega-3 polyunsaturated fatty acids (n-3 PU...
Gestational obesity has major negative impacts on both mothers and their offspring. More than two-th...
Diet of mothers during gestation may impact offspring phenotype. This study evaluated the consequenc...
UNLABELLED: Restriction of protein or energy intake during gestation or early life is linked to deve...
Supplementary Materials: The following are available online at http://www.mdpi.com/2072-6643/11/1/96...