Selective transport of the nuclear pore complex studied through all-atom and coarse-grained molecular dynamics simulations

Miao, Lingling

Language

English

Abstract

As the only pathways connecting the cell???s nucleus and cytoplasm, nuclear pore complexes (NPCs) enable and control the import and export between cell???s cytoplasm and nucleoplasm. The NPC allows small molecules (<40 KDa) to diffuse freely into and out of the nucleus, while excluding large molecules, which are only allowed to pass when bound to transport receptors. Anchored on the inner surface of the NPC central pore are many intrinsically unstructured FG-nups, proteins that contain phenylalanine-glycine repeating sequences (FG-repeats) separated by hydrophilic linker regions. Because of the unstructured nature of FG-nups, no imaging method has been able to capture the collective conformation of these proteins in detail. However, their c...

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Selective transport of the nuclear pore complex studied through all-atom and coarse-grained molecular dynamics simulations

Abstract

Extracted data

Selective transport of the nuclear pore complex studied through all-atom and coarse-grained molecular dynamics simulations

Abstract

Extracted data

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