International audiencePurpose: Glioblastomas (GBM) are highly malignant and heterogeneous gliomas with very poor prognosis. The biological and molecular characterization of these tumors is still challenging and impacts their therapeutic management. Previous genomic surveys have revealed the highly rearranged nature of GBM genome and transcriptome. However, the impacts of tumor DNA aberrations on gene expression remain unclear. Methods: We investigated copy number alterations (CNA) and gene expression to identify causal genetic events in GBM. High-resolution maps of somatic chromosomal alterations were obtained for 20 GBM. Gene expression profiling was carried out on the same tumor samples, and compared to those obtained on nonneoplastic bra...
Available data on genetic events in pediatric grade IV astrocytomas (glioblastoma [pGBM]) are scarc...
The Cancer Genome Atlas Network recently catalogued recurrent genomic abnormalities in glioblastoma ...
The Cancer Genome Atlas Network recently catalogued recurrent genomic abnormalities in glioblastoma ...
International audiencePurpose: Glioblastomas (GBM) are highly malignant and heterogeneous gliomas wi...
International audiencePurpose: Glioblastomas (GBM) are highly malignant and heterogeneous gliomas wi...
International audiencePurpose: Glioblastomas (GBM) are highly malignant and heterogeneous gliomas wi...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
We performed genotyping and exon-level expression profiling on 21 glioblastomas (GBMs) and 19 oligod...
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults. Decade...
Development of model systems that recapitulate the molecular heterogeneity observed among glioblasto...
Development of model systems that recapitulate the molecular heterogeneity observed among glioblasto...
[Background]: Glioblastoma multiforme (GBM) is the most common primary tumor of the central nervous ...
Available data on genetic events in pediatric grade IV astrocytomas (glioblastoma [pGBM]) are scarc...
The Cancer Genome Atlas Network recently catalogued recurrent genomic abnormalities in glioblastoma ...
The Cancer Genome Atlas Network recently catalogued recurrent genomic abnormalities in glioblastoma ...
International audiencePurpose: Glioblastomas (GBM) are highly malignant and heterogeneous gliomas wi...
International audiencePurpose: Glioblastomas (GBM) are highly malignant and heterogeneous gliomas wi...
International audiencePurpose: Glioblastomas (GBM) are highly malignant and heterogeneous gliomas wi...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
International audienceGlioblastoma multiforme shows multiple chromosomal aberrations, the impact of ...
We performed genotyping and exon-level expression profiling on 21 glioblastomas (GBMs) and 19 oligod...
Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults. Decade...
Development of model systems that recapitulate the molecular heterogeneity observed among glioblasto...
Development of model systems that recapitulate the molecular heterogeneity observed among glioblasto...
[Background]: Glioblastoma multiforme (GBM) is the most common primary tumor of the central nervous ...
Available data on genetic events in pediatric grade IV astrocytomas (glioblastoma [pGBM]) are scarc...
The Cancer Genome Atlas Network recently catalogued recurrent genomic abnormalities in glioblastoma ...
The Cancer Genome Atlas Network recently catalogued recurrent genomic abnormalities in glioblastoma ...