Trefoil factor family: unresolved questions and clinical perspectives

Braga Emidio, N.
Hoffmann, W.
Brierley, S.
Muttenthaler, M.

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Publication date

January 2019

DOI

10.1016/j.tibs.2019.01.004

Publisher

Elsevier BV

Journal

Trends in Biochemical Sciences

Abstract

The trefoil factor family of peptides (TFF1, TFF2, TFF3) with their lectin activities play important roles in mucosal protection and repair. However, major gaps in understanding their molecular function have hampered therapeutic development for gastrointestinal disorders. We provide here a critical overview of the status quo.Nayara Braga Emidio, Werner Hoffmann, Stuart M.Brierley, Markus Muttenthale

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Trefoil factor family: unresolved questions and clinical perspectives

Abstract

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Trefoil factor family: unresolved questions and clinical perspectives

Abstract

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