Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval...
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer r...
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer r...
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) suscep...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer r...
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer r...
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) suscep...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 10...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Prostate cancer (PrCa) is the most common non-skin cancer diagnosed among males in developed countri...
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer r...
Genome-wide association studies (GWAS) have identified 76 variants associated with prostate cancer r...
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) suscep...