International audienceSAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting the supply of the dNTP substrates. Yet, phosphorylation of T592 downregulates SAMHD1 antiviral activity, but not its dNTPase function, implying that additional mechanisms contribute to viral restriction. Here, we show that SAMHD1 is SUMOylated on residue K595, a modification that relies on the presence of a proximal SUMO-interacting motif (SIM). Loss of K595 SUMOylation suppresses the restriction activity of SAMHD1, even in the context of the constitutively active phospho-ablative T592A mutant but has no impact on dNTP depletion. Conversely, the artificial fusion of SUMO2 to a non-S...
Abstract Background The restriction factor SAMHD1 regulates intracellular nucleotide level by degrad...
SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cel...
BACKGROUND: Human SAMHD1 is a triphosphohydrolase that restricts the replication of retroviruses, re...
International audienceSAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 r...
Since its discovery seven years ago, SAMHD1 has emerged as an important cellular factor that limits ...
Depuis sa découverte il y a sept ans, les recherches intensives sur SAMHD1 en ont fait un facteur ce...
SummarySAMHD1 is a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs)...
ABSTRACT Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosp...
SummarySAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4+ T cells. Here, we show that ...
Background: Human SAMHD1 is a triphosphohydrolase that restricts the replication of retroviruses, re...
Human andmouse SAMHD1 proteins block human immunodeficiency virus type 1 (HIV-1) infection in noncyc...
<div><p>SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4<sup>+</sup> T-cells. Mos...
SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4+ T cells. Here, we show that SAMHD1 ...
International audienceSAMHD1 restricts HIV-1 replication in myeloid andquiescent CD4+T cells. Here, ...
SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cel...
Abstract Background The restriction factor SAMHD1 regulates intracellular nucleotide level by degrad...
SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cel...
BACKGROUND: Human SAMHD1 is a triphosphohydrolase that restricts the replication of retroviruses, re...
International audienceSAMHD1 is a cellular triphosphohydrolase (dNTPase) proposed to inhibit HIV-1 r...
Since its discovery seven years ago, SAMHD1 has emerged as an important cellular factor that limits ...
Depuis sa découverte il y a sept ans, les recherches intensives sur SAMHD1 en ont fait un facteur ce...
SummarySAMHD1 is a cellular enzyme that depletes intracellular deoxynucleoside triphosphates (dNTPs)...
ABSTRACT Sterile α motif and HD domain-containing protein 1 (SAMHD1) is a dNTP triphosphate triphosp...
SummarySAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4+ T cells. Here, we show that ...
Background: Human SAMHD1 is a triphosphohydrolase that restricts the replication of retroviruses, re...
Human andmouse SAMHD1 proteins block human immunodeficiency virus type 1 (HIV-1) infection in noncyc...
<div><p>SAMHD1 restricts HIV-1 infection of myeloid-lineage and resting CD4<sup>+</sup> T-cells. Mos...
SAMHD1 restricts HIV-1 replication in myeloid and quiescent CD4+ T cells. Here, we show that SAMHD1 ...
International audienceSAMHD1 restricts HIV-1 replication in myeloid andquiescent CD4+T cells. Here, ...
SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cel...
Abstract Background The restriction factor SAMHD1 regulates intracellular nucleotide level by degrad...
SAMHD1 is a host restriction factor for human immunodeficiency virus 1 (HIV-1) in cultured human cel...
BACKGROUND: Human SAMHD1 is a triphosphohydrolase that restricts the replication of retroviruses, re...