EFFECT OF NARINGENIN ON LIPIDS, LIPOPROTEINS AND LIPID METABOLISING ENZYMES IN 7,12-DIMETHYL BENZ(A)ANTHRACENE-INDUCED MAMMARY CARCINOGENESIS IN SD RATS

Objective: Mammary carcinoma is one of the most common and prominent cause of cancer-related death in women worldwide. The role of fatty acid synthesis and altered lipid metabolism in cancer progression was well established. Cancer cells undergo enhanced de-novo lipogenesis and liver uptake. The magnitudes of bioflavonoids in lipid management against various cancers have been established. In the present study, we evaluated the efficacy of a bioflavonoid Naringenin (NGN) to re-establish the lipid metabolic alterations in 7, 12-dimethyl benz (a) anthracene (DMBA)-induced mammary carcinoma in Sprague Dawley (SD) rats.Methods: DMBA-induced mammary carcinoma was developed using air pouch technique (20 mg in 0.5 ml olive oil) following a 118 d experimental protocol. NGN (40, 80 mg/kg b. w.; i. p.) was given for 28 d after promotional stage (90 d) of carcinoma bearing animals. The changes in body weight (b. w.), lipids, lipoproteins and lipid metabolising enzymes (LME) level were estimated and correlated with anticancer potentials of NGN.Results: The results indicated a dose dependant significant (p<0.05) restorative effect of NGN on body weight of cancer-bearing animals. The changes in lipid level in plasma and liver tissue were re-established after treatment. Lipoproteins and LME were also changed in cancer-bearing animals with that of NGN treatment significantly (p<0.01).Conclusion: NGN potentially reverted the changes in body weight, lipid profile, LME that config. its anticancer potential against mammary carcinogenesis.Â