SYNTHESIS AND EVALUATION OF ZINC SUBSTITUTED MAGNETITE NANOPARTICLES FOR DRUG DELIVERY SYSTEMS

Objective: The aim of this study is to synthesis zinc substituted magnetite nanoparticles with higher values of saturation magnetization and testing its antibacterial activity.Methods: The particles of zinc substituted magnetite with the composition ofZnxFe3-xO4 (Ñ…Â = 0.0, 0.2, 0.3, 0.4, 0.5) were prepared using a chemical condensation method. The crystalline structure, morphology and the magnetic properties of the ferrite particles were studied by means of X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer. The synthesized ZnMNPs40 were tested for their antibacterial and antifungal activity by disc diffusion method.Results: X-ray diffraction analysis showed that the nanoparticles formed in the present synthesis were crystalline (spinel type) in nature. The size of the synthesized nanoparticles was in the range of 3-13 nm obtained from TEM image. Magnetic measurements at 300 Кhavede monstrated the super paramagnetic behavior of the nanoparticles. The synthesized ZnMNPs40 nanoparticles exhibited antibacterial activity against bacterial strains like Bacillus subtilis, Escherichia coli, Staphylococcus aureus and antifungal activity.Conclusion: Zinc has been incorporated into the crystal structure of magnetite to enhance the saturation magnetization of nanoparticles. The synthesized ZnMNPs had a nanometric size and a superparamagnetic behavior, exhibited effective antibacterial property.Â