ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF LEAF AND BARK OF DIOSPYROS VIRGINIANA IN YEAST INDUCED PYREXIA

Objective: To evaluate the antipyretic effect of the ethanolic extract of leaf and bark of Diospyros virginiana Linn against brewer yeast induced pyrexia model in albino rats of both sexes was investigated.Methods: The Pyrexia was induced by subcutaneously injecting 20% w/v brewer's yeast suspension (10 ml/kg) into the animals. After the injection, the rectal temperature of each rat was measured. Paracetamol (150 mg/kg) was used as the standard drug.Results: The results showed that the ethanol extracts of leaf of Diospyros virginiana possessed significant antipyretic effect compared to the bark extract.Conclusion: This study provides evidences for the antipyretic activity of Diospyros virginiana which could partly contribute to its ethno medical use