DEVELOPMENT, OPTIMIZATION AND EVALUATION OF DIFFERENT HERBAL FORMULATIONS FOR WOUND HEALING

Objective: This study was done for comparative evaluation of different herbal formulations used for topical delivery of therapeutic agents at the time of injury to accelerate skin repair in the shortest time possible, with minimal pain, discomfort and scarring to the patient during the wound healing process.Methods: Topical application of ointments and gels prepared from the methanolic extract of Aegle marmelos leaves and Mucuna pruriens seeds were formulated and evaluated for its efficacy and safety. General formulation approaches towards achieving optimum physical properties and topical delivery characteristics for an active wound healing dosage form were considered for different herbal formulations.Results: All formulation showed good stability during storage and no major changes observed after carrying out other physiochemical evaluations and during an entire storage period. Differences in wound healing were observed between the various treatments and compared to the herbal formulation which has promising effect on the wound healing process.Conclusions: The results obtained were encouraging and gel-based formulations produced better wound healing than emulsifying ointment formulations. The results demonstrated that the tested hydrogel had promising healing effect in skin injuries and it will aid in identifying and targeting the many aspects of the complex wound healing process