Add to ORKGObjective: The aim of this study was to investigate CYP1A interaction of crude extracts (ethanolic, methanolic, hydromethanolic & aqueous) of Withania somnifera and its principal phytoconstituents (withaferin-A and withanolide-A) in rat and human liver microsomes.Methods: In vitro study were carried out in both rat & human liver microsomes while, in vivo CYP1A interaction potential was investigated by administering the methanolic extract of Withania somnifera orally at a dose of 500 mg/kg in male Wistar rats using probe substrate technique.Results: The results of this study revealed that IC50 values of all the crude extracts of Withania somnifera and its principal phytoconstituents (withaferin–A & withanolide–A) were found t...
Despite increasing recognition of potential untoward interactions between herbal products and conven...
Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage...
Traditional herbal medicines are now increasingly being appreciated with Western models o...
Background: Studies have suggested an increasing practice of concurrent herb-drug consumption. One o...
Background: Studies have suggested an increasing practice of concurrent herb-drug consumption. One o...
Background: Hepatic diseases are a major cause of morbidity and disability of work force throughout ...
A resurgence in the use of medical herbs in the Western world, and the co-use of modern and traditio...
BACKGROUND: Increasing use of medicinal herbs as nutritional supplements and traditional medicines f...
A resurgence in the use of medical herbs in the Western world, and the co-use of modern and traditio...
To date, a number of significant herbal drug interactions have their origins in the alteration of cy...
The extract from Mitragyna speciosa has been widely used as an opium substitute, mainly due to its m...
Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could inf...
Herbal medicines, such as St John's wort, garlic, gingko, and ginseng, are commonly used comple...
The increase in the use of herbal products, particularly in patients taking conventional medicine, h...
Cytochrome P450 (CYP P450) enzymes are a superfamily of mono-oxygenases that are found in all kingdo...
Despite increasing recognition of potential untoward interactions between herbal products and conven...
Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage...
Traditional herbal medicines are now increasingly being appreciated with Western models o...
Background: Studies have suggested an increasing practice of concurrent herb-drug consumption. One o...
Background: Studies have suggested an increasing practice of concurrent herb-drug consumption. One o...
Background: Hepatic diseases are a major cause of morbidity and disability of work force throughout ...
A resurgence in the use of medical herbs in the Western world, and the co-use of modern and traditio...
BACKGROUND: Increasing use of medicinal herbs as nutritional supplements and traditional medicines f...
A resurgence in the use of medical herbs in the Western world, and the co-use of modern and traditio...
To date, a number of significant herbal drug interactions have their origins in the alteration of cy...
The extract from Mitragyna speciosa has been widely used as an opium substitute, mainly due to its m...
Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could inf...
Herbal medicines, such as St John's wort, garlic, gingko, and ginseng, are commonly used comple...
The increase in the use of herbal products, particularly in patients taking conventional medicine, h...
Cytochrome P450 (CYP P450) enzymes are a superfamily of mono-oxygenases that are found in all kingdo...
Despite increasing recognition of potential untoward interactions between herbal products and conven...
Sophora flavescens is a Chinese medicinal herb used for the treatment of gastrointestinal hemorrhage...
Traditional herbal medicines are now increasingly being appreciated with Western models o...