GREEN AND CHEMICALLY SYNTHESIZED COPPER OXIDE NANOPARTICLES-A PRELIMINARY RESEARCH TOWARDS ITS TOXIC BEHAVIOUR

Objectives: Metal oxide nanoparticles have been widely explored in various applications like biosensors, solar cells, biomedical applications in the recent times. However, biological applications of these nanoparticles needs to be low compatible and this is often found as a limitation. The present study aims to compare CuO nanoparticles prepared by chemical and green route to evaluate its suitability for biological applications.Methods: CuO nanoparticles prepared by both methods were characterized by using XRD, UV-Visible spectroscopy, FTIR, ZETA for phase structure, size, the functional group presence, thermal stability and surface charge stability respectively. Free radical scavenging potential and phenolic contents, was assessed for biologically prepared CuO nanoparticles.Results: Green synthesized CuO nanoparticles were found to have higher free radical scavenging potential with good colloidal stability and was also found to have well defined monodisperse nature as compared to chemically synthesized CuO nanoparticles. Evaluation of toxicity in cell line LLC PK1 was found to be slightly toxic.Conclusion: Green synthesized CuO nanoparticles was found to have good stability when compared to chemically synthesized ones showing that they possess desired attributes to be used for biomedical applications.Â