ABNORMALNOSTI PUPČANE VRPCE U PATOHISTOLOŠKIM NALAZIMA : RETROSPEKTIVNA JEDNOGODIŠNJA STUDIJA

Objectives: to determine the most common abnormalities of the UC and their relation to other placental pathologies. Secondary outcome was to determine UC morphological characteristics in placentas with UC abnormalities and to compare them with the placentas without UC abnormalities. Likewise, we aimed to determine gestational age, fetal birth weight, placental weight, placental diameter and thickness of the placentas with UC abnormalities and without UC abnormalities and to compare them. Materials and methods: retrospective study within the time span from January 1st 2020 to December 31st 2020 was conducted at the department of Pathology, Forensic Medicine and Cytology , University Hospital of Split. Placental pathohistological reports that had following International classification of diseases codes (ICD code) for placental abnormalities: O41, O43, O45, O69, and Q27.0 were included in the study. Exclusion criteria were all of the placentas with insufficient data or misplaced ICD codes. Results: From the 202 placental pathohistological reports with various placental pathology, 76 (37,65%) had an umbilical cord pathology. The most common umbilical cord abnormality was the presence of UC abnormality combined with other placental abnormalities, found in 51 placentas, of which the combined fetal and maternal inflammatory response, found in 34 (66,7%) placentas was the most common one (P<0,0001). The least common UC abnormalites in placentas with UC abnormality were the fetal vascular malperfusion, velamentous insertion and true knot. The most common placental abnormality among placentas without UC abnormalities was maternal vascular malperfusion, that was noted in 59 (4,8%) placentas, while villitis basalis was noted in just one placenta (P<0,0001). Conclusion: The most common UC abnormality according to the pathohistological reports was the abnormality of the UC combined with other placental abnormalities. In order to understand the pathology of UC better and its effect on perinatal morbidity and mortality further studies are necessary.Ciljevi: utvrditi najučestaliju abnormalnost pupčane vrpce (PV) i odnos prema drugim patološkim lezijama posteljice. Sekundarni cilj je bio utvrditi morfološke karakteristike PV posteljica s abnormalnostima PV i rezultate usporediti s posteljicama koje su imale uredne PV. Također, odrediti gestacijsku dob, porođajnu masu djeteta, masu posteljice, dijametar i debljinu posteljice u skupini posteljica s abnormalnostima PV i rezultate usporediti s posteljicama urednih PV. Materijali i metode: retrospektivna jednogodišnja studija, u razdoblju od 1. siječnja 2020. godine do 31. prosinca 2020. godine, provedena je na Odjelu Patologije, Kliničkog zavoda za Patologiju, Sudsku medicinu i Citologiju, KBC Split. U studiju su uključeni svi patohistološki nalazi posteljica sa sljedećim šiframa Međunarodne Klasifikacije Bolesti (MKB): O41, O43, O45, O69 i Q27.0. Iz studije su isključeni svi patohistološki nalazi posteljica čiji su podatci bili nepotpuni ili su MKB šifre bile pogrešno dodijeljene. Rezultati: U studiju je uključeno 202 patohistološka nalaza posteljica s bilo kojom patologijom, od čega je bilo 76 (37,65%) posteljica koje su imale PV abnormalnosti. Najučestalija abnormalnost PV je abnomalnost PV udružena s drugim abnormalnostima posteljice, što je zabilježeno u 51 posteljci, od čega je najučestalija abnormalnost bila udruženi fetalni i majčin upalni odgovor zabilježen u 34 posteljice (P<0,0001). Najrjeđa izolirana abnormalnost PV je bila fetalna vaskularna malperfuzija, velamentozna insercija i pravi čvor pupkovine. Najučestalija lezija posteljice u skupini posteljica bez abnormalnsti PV je bila maternalna vaskularna malperfuzija, zabilježena u 59 posteljica, a najrjeđa bazalni vilitis zabilježen u jednoj poteljici (P