Vasculo-Protective Cover: A Novel Action of Metformin

Type 2 diabetes is associated with multiple changes/complications in the body that affects almost every organ and system. Inthe cardiovascular system main pathology lies in the vascular endothelium leading to atherosclerosis and arteriosclerosis.Different treatment options are available for diabetes including both oral and injectable drugs. Oral drugs have better compliancelike Sulfonylureas, Alpha glucosidase inhibitors, Glitazones and Maglitinides. These groups of anti-hyperglycemic drugsmaintain blood glucose level, providing diabetics cost effective better life through a physiological route. However, it has beendocumented that these drugs do not delay vascular complications in diabetic patients. Metformin is the first line oral anti-diabeticdrug from biguanide group used to treat type 2 diabetes mellitus. It is a euglycemic agent which decreases glucose levels andhave additional benefit of decreasing the progression of vascular effects in multiple ways