PD-L1 Dependent Immunogenic Landscape in Hot Lung Adenocarcinomas Identified by Transcriptome Analysis
- Jutta Kirfel
- Christiane Charlotte Kümpers
- Anke Fähnrich
- Carsten Heidel
- Mladen Jokic
- Ignacija Vlasic
- Sebastian Marwitz
- Torsten Goldmann
- Helen Pasternack
- Sabine Bohnet
- Danny Jonigk
- Mark P. Kühnel
- Anne Offermann
- Hauke Busch
- Sven Perner
DOIAbstract
Background: Lung cancer is the most frequent cause of cancer-related deaths worldwide. The clinical development of immune checkpoint blockade has dramatically changed the treatment paradigm for patients with lung cancer. Yet, an improved understanding of PD-1/PD-L1 checkpoint blockade-responsive biology is warranted. Methods: We aimed to identify the landscape of immune cell infiltration in primary lung adenocarcinoma (LUAD) in the context of tumoral PD-L1 expression and the extent of immune infiltration (“hot” vs. “cold” phenotype). The study comprises LUAD cases (n = 138) with “hot” (≥150 lymphocytes/HPF) and “cold” (50%) and negative (<1%) tumor PD-L1 expression, respectively. Tumor samples were immunohistochemically analyzed for express...
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