Hepatitis B virus (HBV), the well-studied oncovirus that contributes to the majority of hepatocellular carcinomas (HCC) worldwide, can cause a severe inflammatory microenvironment leading to genetic and epigenetic changes in hepatocyte clones. HBV replication contributes to the regulation of DNA methyltransferase gene expression, particularly by X protein (HBx), and subsequent methylation changes may lead to abnormal transcription activation of adjacent genes and genomic instability. Undoubtedly, the altered expression of these genes has been known to cause diverse aspects of infected hepatocytes, including apoptosis, proliferation, reactive oxygen species (ROS) accumulation, and immune responses. Additionally, pollutant-induced DNA methyla...
<div><p>Background</p><p>It is well known that chronic inflammation plays a pivotal role in the deve...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from chro...
Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and...
Gene inactivation through DNA hypermethylation plays a pivotal role in carcinogenesis. This study ai...
Chronic infection of the liver by the hepatitis B virus (HBV) is associated with increased risk for ...
Worldwide, it is estimated that more than 400 million people are currently living with chronic hepat...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
2 Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from ch...
Hepatocellular carcinoma (HCC) remains one of the most prevalent malignant diseases worldwide, and t...
BACKGROUND: It is well known that chronic inflammation plays a pivotal role in the development of he...
Hepatitis B virus (HBV) infection is highly correlated with hepatocellular carcinoma (HCC) and many ...
It is well known that chronic inflammation plays a pivotal role in the development of hepatitis B vi...
<div><p>Background</p><p>It is well known that chronic inflammation plays a pivotal role in the deve...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from chro...
Recent studies have identified the presence of methylation in the hepatitis B virus (HBV) genome and...
Gene inactivation through DNA hypermethylation plays a pivotal role in carcinogenesis. This study ai...
Chronic infection of the liver by the hepatitis B virus (HBV) is associated with increased risk for ...
Worldwide, it is estimated that more than 400 million people are currently living with chronic hepat...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
2 Control of viral replication is a major therapeutic goal to reduce morbidity and mortality from ch...
Hepatocellular carcinoma (HCC) remains one of the most prevalent malignant diseases worldwide, and t...
BACKGROUND: It is well known that chronic inflammation plays a pivotal role in the development of he...
Hepatitis B virus (HBV) infection is highly correlated with hepatocellular carcinoma (HCC) and many ...
It is well known that chronic inflammation plays a pivotal role in the development of hepatitis B vi...
<div><p>Background</p><p>It is well known that chronic inflammation plays a pivotal role in the deve...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...
This review focuses on the significance of deregulation of epigenetic mechanisms by the hepatitis B ...