Novel drugs are needed to treat a variety of persistent diseases caused by intracellular bacterial pathogens. Virulence pathways enable many functions required for the survival of these pathogens, including invasion, nutrient acquisition, and immune evasion. Inhibition of virulence pathways is an established route for drug discovery; however, many challenges remain. Here, we propose the biggest problems that must be solved to advance the field meaningfully. While it is established that we do not yet understand the nature of chemicals capable of permeating into the bacterial cell, this problem is compounded when targeting intracellular bacteria because we are limited to only those chemicals that can permeate through both human and bacterial ...
Although antibiotics have been indispensable in the advancement of modern medicine, there are downsi...
Antibiotics are failing fast, and the development pipeline remains alarmingly dry. New drug research...
The identification of potent in vitro inhibitors of essential bacterial targets is relatively straig...
Although instances of antibiotic resistance are steadily rising, traditional screening platforms hav...
ABSTRACT We sought a new approach to treating infections by intracellular bacteria, namely, by alter...
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to conti...
Antibiotic resistance is an increasing problem in the battle against (bacterial) infectious diseases...
Resistance of important bacterial pathogens to common antimicrobial therapies and the emergence of m...
The prevalence of bacterial pathogens being resistant to antibiotic treatment is increasing worldwid...
Antibiotic resistance is a serious public health concern at the global level. Available antibiotics ...
In recent years, chemical biology and chemical genomics have been increasingly applied to the field ...
Intracellular bacterial pathogens are hard to treat because of the inability of conventional antimic...
Abstract Intracellular bacterial pathogens are hard to treat because of the inability of convention...
Antibiotic resistance continues to reduce the number of available antibiotics, increasing the need f...
The emergence and increasing prevalence of bacterial strains that are resistant to available antibio...
Although antibiotics have been indispensable in the advancement of modern medicine, there are downsi...
Antibiotics are failing fast, and the development pipeline remains alarmingly dry. New drug research...
The identification of potent in vitro inhibitors of essential bacterial targets is relatively straig...
Although instances of antibiotic resistance are steadily rising, traditional screening platforms hav...
ABSTRACT We sought a new approach to treating infections by intracellular bacteria, namely, by alter...
Bacterial resistance to antibiotics inevitably results from their clinical use, and we have to conti...
Antibiotic resistance is an increasing problem in the battle against (bacterial) infectious diseases...
Resistance of important bacterial pathogens to common antimicrobial therapies and the emergence of m...
The prevalence of bacterial pathogens being resistant to antibiotic treatment is increasing worldwid...
Antibiotic resistance is a serious public health concern at the global level. Available antibiotics ...
In recent years, chemical biology and chemical genomics have been increasingly applied to the field ...
Intracellular bacterial pathogens are hard to treat because of the inability of conventional antimic...
Abstract Intracellular bacterial pathogens are hard to treat because of the inability of convention...
Antibiotic resistance continues to reduce the number of available antibiotics, increasing the need f...
The emergence and increasing prevalence of bacterial strains that are resistant to available antibio...
Although antibiotics have been indispensable in the advancement of modern medicine, there are downsi...
Antibiotics are failing fast, and the development pipeline remains alarmingly dry. New drug research...
The identification of potent in vitro inhibitors of essential bacterial targets is relatively straig...