The Polygenic and Monogenic Basis of Blood Traits and Diseases
- Vuckovic, D.
- Bao, E.L.
- Akbari, P.
- Lareau, C.A.
- Mousas, A.
- Jiang, T.
- Chen, M.-H.
- Raffield, L.M.
- Tardaguila, M.
- Huffman, J.E.
- Ritchie, S.C.
- Megy, K.
- Ponstingl, H.
- Penkett, C.J.
- Albers, P.K.
- Wigdor, E.M.
- Sakaue, S.
- Moscati, A.
- Manansala, R.
- Lo, K.S.
- Qian, H.
- Akiyama, M.
- Bartz, T.M.
- Ben-Shlomo, Y.
- Beswick, A.
- Bork-Jensen, J.
- Bottinger, E.P.
- Brody, J.A.
- van Rooij, F.J.A.
- Chitrala, K.N.
- Wilson, P.W.F.
- Choquet, H.
- Danesh, J.
- Di Angelantonio, E.
- Dimou, N.
- Ding, J.
- Elliott, P.
- Esko, T.
- Evans, M.K.
- Felix, S.B.
- Floyd, J.S.
- Broer, L.
- Grarup, N.
- Guo, M.H.
- Guo, Q.
- Greinacher, A.
- Haessler, J.
- Hansen, T
- Howson, J.M.M.
- Huang, W.
- Jorgenson, E.
- Kacprowski, T.
- Kähönen, M.
- Kamatani, Y.
- Kanai, M.
- Karthikeyan, S.
- Koskeridis, F.
- Lange, L.A.
- Lehtimäki, T.
- Linneberg, A.
- Liu, Y.
- Lyytikäinen, L.-P.
- Manichaikul, A.
- Matsuda, K.
- Mohlke, K.L.
- Mononen, N.
- Murakami, Y.
- Nadkarni, G.N.
- Nikus, K.
- Pankratz, N.
- Pedersen, O.
- Preuss, M.
- Psaty, B.M.
- Raitakari, O.T.
- Rich, S.S.
- Rodriguez, B.A.T.
- Rosen, J.D.
- Rotter, J.I.
- Schubert, P.
- Spracklen, C.N.
- Surendran, P.
- Tang, H.
- Tardif, J.-C.
- Ghanbari, M.
- Völker, U.
- Völzke, H.
- Watkins, N.A.
- Weiss, S.
- Cai, N.
- Kundu, K.m
- Watt, S.B.
- Walter, K.
- Zonderman, A.B.
- Cho, K.
- Li, Y.
- Loos, R.J.F.
- Knight, J.C.
- Georges, M.
- Stegle, O.
- Evangelou, E.
- Okada, Y.
- Roberts, D.J.
- Inouye, M.
- Johnson, A.D.
- Auer, P.L.
- Astle, W.J.
- Reiner, A.P.
- Butterworth, A.S.
- Ouwehand, W.H.
- Lettre, G.
- Sankaran, V.G.
- Soranzo, N.
DOIAbstract
Blood cells play essential roles in human health, underpinning physiological processes such as immunity, oxygen transport, and clotting, which when perturbed cause a significant global health burden. Here we integrate data from UK Biobank and a large-scale international collaborative effort, including data for 563,085 European ancestry participants, and discover 5,106 new genetic variants independently associated with 29 blood cell phenotypes covering a range of variation impacting hematopoiesis. We holistically characterize the genetic architecture of hematopoiesis, assess the relevance of the omnigenic model to blood cell phenotypes, delineate relevant hematopoietic cell states influenced by regulatory genetic variants and gene networks, ...
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