In the modern world, humans are exposed to a wide range of chemicals throughout their life. Human risk assessment of chemicals is of considerable public health importance and provides means to derive safe levels of acute and chronic exposure for subgroups of the human population including neonates, children, elderly and populations of different geographical ancestry and genetic polymorphisms. The application of pathway-related kinetic data to address human variability in the quantification of hazard has potential to reduce uncertainty and better characterize variability compared with the use of traditional default uncertainty factors. This thesis aims to 1) quantify human variability by means of Bayesian meta-analysis for a range of phase I...
Background: Characterizing variability in the extent and nature of responses to environmental exposu...
Exposure to chemical hazards is a growing concern in today’s society, and it is of utmost interest t...
International audiencePhysiologically based pharmacokinetic (PBPK) models have proven to be successf...
In the modern world, humans are exposed to a wide range of chemicals throughout their life. Human ri...
This thesis deals with the statistical analysis of human variability in kinetics for the major metab...
International audienceQuantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provi...
A 100-fold uncertainty factor is used to derive acceptable daily intakes for compounds causing thres...
L'homme est exposé quotidiennement à divers produits chimiques provenant de différentes sources, not...
The derivation of safe levels of exposure in humans for compounds that are assumed to cause threshol...
CYP3A4 constitutes the major liver cytochrome P450 isoenzyme and is responsible for the oxidation of...
Human variability in the kinetics of a number of phase I (CYP2A6, CYP2C9, CYP2E1, alcohol dehydrogen...
National audienceToxicological studies aim at protecting human populations by quantifying the damage...
The derivation of safe levels of exposure in humans for compounds that are assumed to cause threshol...
Human variability in the kinetics of CYP2D6 substrates has been quantified using a database of compo...
International audienceCharacterizing variability in the extent and nature of responses to environmen...
Background: Characterizing variability in the extent and nature of responses to environmental exposu...
Exposure to chemical hazards is a growing concern in today’s society, and it is of utmost interest t...
International audiencePhysiologically based pharmacokinetic (PBPK) models have proven to be successf...
In the modern world, humans are exposed to a wide range of chemicals throughout their life. Human ri...
This thesis deals with the statistical analysis of human variability in kinetics for the major metab...
International audienceQuantifying variability in pharmacokinetics (PK) and toxicokinetics (TK) provi...
A 100-fold uncertainty factor is used to derive acceptable daily intakes for compounds causing thres...
L'homme est exposé quotidiennement à divers produits chimiques provenant de différentes sources, not...
The derivation of safe levels of exposure in humans for compounds that are assumed to cause threshol...
CYP3A4 constitutes the major liver cytochrome P450 isoenzyme and is responsible for the oxidation of...
Human variability in the kinetics of a number of phase I (CYP2A6, CYP2C9, CYP2E1, alcohol dehydrogen...
National audienceToxicological studies aim at protecting human populations by quantifying the damage...
The derivation of safe levels of exposure in humans for compounds that are assumed to cause threshol...
Human variability in the kinetics of CYP2D6 substrates has been quantified using a database of compo...
International audienceCharacterizing variability in the extent and nature of responses to environmen...
Background: Characterizing variability in the extent and nature of responses to environmental exposu...
Exposure to chemical hazards is a growing concern in today’s society, and it is of utmost interest t...
International audiencePhysiologically based pharmacokinetic (PBPK) models have proven to be successf...