A study was conducted to determine the influence of heat exchanger design on the performance of residential air-conditioning systems using zeotropic mixtures as HCFC-22 alternatives. A computer simulation of the evaporator was developed to model various evaporator designs, and was validated with experimental data collected under controlled air and refrigerant conditions with both HCFC-22 and a zeotropic mixture of HFC-32/HFC- 134a/HFC-125 (23%/52%/25%). The model predictions of heat transfer, pressure drop, and temperature profIles were in very good agreement with the experimental data. An effectiveness-type model for combined heat and mass transfer was developed and implemented in the simulation, resulting in increased computation...