Koriokarcinom maternice – prikaz slučaja

Choriocarcinoma is one of the histological types of entities called gestational trophoblastic neoplasia (GTN) that refers to a rare group of malignancies that are formed by abnormal proliferation of trophoblastic tissue. Choriocarcinoma is the most aggressive GTN histological type and is characterized by early vascular invasion and disseminated disease. The clinical presentation depends on the spread of the disease and the location of the seedlings. In this paper we present the case of a 32-year-old patient sent to our Department for a specific oncological treatment of uterine choriocarcinoma diagnosed in an external institution. The disease is according to FIGO and WHO scale classified as III stage, low risk and chemotherapy with methotrexate and folic acid is indicated. The chemotherapy achieved negativity of the initially elevated tumor marker human chorionic gonadotropin (hCG) and full regression of lesions described in computerized tomography (CT).Koriokarcinom jedan je od histoloških tipova gestacijske trofoblastične neoplazije (GTN), rijetke skupine malignoma nastale abnormalnom proliferacijom tkiva trofoblasta i predstavlja najagresivniji histološki tip GTN. Odlikuje se ranim krvožilnim bujanjem i udaljenim presadnicama. Klinička slika ovisi o proširenosti bolesti i smještaju presadnica. U ovom radu prikazan je slučaj 32 godišnje bolesnice upućene u našu ustanovu radi specifičnog liječenja koriokarcinoma maternice dijagnosticiranog u drugoj ustanovi. Bolest je prema FIGO i WHO ljestvici klasificirana u III stadij niskog rizika. Liječenje metotreksatom i folnom kiselinom dovelo je do negativizacije početno izrazito povišenog tumorskog biljega humanog korionskog gonadotropina (hCG) i potpunog povlačenja promjena opisanih CT-om