Hiperferitinemija i COVID-19 ?

It has been repeatedly described that increased serum ferritin concentration or hyperferritinemia is as- sociated with COVID-19, especially with more severe forms of this disease. Ferritin is a molecule whose concentration is determined as a marker of reflecting the body’s iron supply and less significantly as a marker of inflammation of infectious and non-infectious origin. The expression of this vital molecule for iron metabolism is therefore regulated, primarily by an iron- dependent mechanism. However, in addition to this regulation, there appears to be feedback between ferritin and cytokines in the control of pro-inflammatory and anti-inflammatory mediators. This review paper includes basic data on ferritin and the potential causes and consequences of hyper- ferritinemia with implications for COVID-19.Poznato je da je povećana koncentracija feritina u serumu ili hiperferitinemija povezana s COVID-19, posebno u težim oblicima ove bolesti. Feritin je molekula čija se koncentracija određuje kao biljeg koji odražava opskrbu organizma sa željezom, te manje značajno kao biljeg upale infektivnog i neinfektivnog podrijetla. Ekspresija ove molekule neophodne za metabolizam željeza stoga je regulirana, prvenstveno mehanizmom koji ovisi o željezu. Međutim, pored ove regulacije, čini se da postoje i povratne informacije između feritina i citokina u kontroli proupalnih i protuupalnih medijatora. Ovaj pregledni članak uključuje osnovne podatke o feritinu i potencijalnim uzrocima i posljedicama hiperferitinemije s implikacijama na COVID-19