Lipoproteins in serum in non-insulin dependent diabetes mellitus after treatment with insulin

Koncentracija HbA,, HDL-kolesterola, LDL-kolesterola, ukupnog kolesterola i triglicerida određivana je kod 18 bolesnika s insulin neovisnom šećernom bolesti prethodno liječenih glibenklamidom, te prije i tri mjeseca nakon kombinirane terapije insulinom i glibenklamidom. Koncentracija HbA, značajno je pala nakon tri mjeseca (p 0,05)), a LDL-kolesterol je blago, ali nesignifikantno pao (4,32 + 0,87 mmol/1 na 4,01 + 0,99 mmol/1, p > 0,05). Signifikantno su pali i ukupni kolesterol (p < 0,05) i trigliceridi (p < 0,01), što vjerojatno odražava pad VLDL-kolesterola. Nije ustanovljena značajna povezanost između HDL-kolesterola i HbA,.HbA1, HDL-cholesterol, total cholesterol and tri- glyceride concentrations were measured in 18 patients vith non-insulin dependent diabetes mellitus previoisly treated with glibenclamide, before and three nonths after the combined treatment with insulin and glibenclamide. HbA, concentration fell significantly after three months (p 0.05), whereas LDL-cholesterol fell slightly but insignificantly (4.32 + 0.87 mmol/L to 4.01 + 0.99 mmol/L, p > 0.05). There was a significant reduction in total cholesterol (p < 0.05) and triglyceride concentrations (p < 0.01), probably reflecting the fall in VLDL-cholesterol concentration. No significant connection has been observed between HbAj and HDL-cholesterol concentrations