Multiple obesity related mechanisms of kidney disease.

Posljednjih desetak godina svjedoci smo da je u središtu medicinske zbilje različitih struka interdisciplinarnost, dominantno gledajući iz perspektive vaskularnoga zdravlja, a zbog razvoja molekularne fiziologije i genetike, što omogućuje translacijski pristup ne samo zbrinjavanja bolesnika nego i prevencije bolesti. Aktualnost problema debljine i uloge bubrega u smanjenju kardiovaskularnog rizika očituje se osnivanjem The Council on Kidney in Cardiovascular Disease, u sklopu American Heart Association koji pristupa problemu pretilosti kao dijelu translacijske medicine. Rano prepoznavanje problema pretilosti vodi prema smanjivanju posljedica bolesti ne samo bubrega nego i cjelokupnoga kardiovaskularnog sustava uz nastavak liječenja interaktivnim pristupom u kontinuitetu od dječje do zdravstvene zaštite odrasle dobi. Bitno je promijeniti pristup sagledavanju problema vezanih za pretilost, posebice stoga što su masne stanice hormonski živo aktivno tkivo koje luči brojne citokine koji stimuliraju angiogenezu uzrokujući sustavno upalno zbivanje.In the last decade, we have witnessed a tendency of various medical professions to focus on an interdisciplinary approach, predominantly from the aspect of vascular health and based on advances in molecular physiology and genetics offering a translational approach not only in patient management but also for prevention of disease. The topical issue of obesity and the role of kidney in cardiovascular risk reduction have manifested through establishment of the Council on Kidney in Cardiovascular Disease at the American Heart Association to tackle the issue of obesity as part of translational medicine. Early recognition of the problem of obesity leads to reducing the sequels of not only kidney disease but also of the entire cardiovascular system, along with continuing treatment with interactive approach from pediatric through adult health care. It is crucial to change approach to the problem of obesity, especially because adipose cells are a hormonally active tissue secreting numerous cytokines that stimulate angiogenesis, thus causing systemic inflammatory event