Polarographic Behaviour of Some Potential Antineoplastic Benzothiazolylazopyrazoles

The present paper summarises the electrochemical behaviour of 4-benzothiazolylazo-N-thiocarbamoyl-3,5-dimethyl pyrazoles. The reduction of above compounds takes place in a single 2e wave at d.m.e. corresponding to the reduction of azo group. All the compounds give irreversible waves at pR values pR > 3.0 and reversible waves at pR values pR < 3.0. All waves are diffusion controlled and half-wave potentials pR dependent. The effect of substituents has been determined quantitatively by the application of Hammett equation. A plausible mechanism has been suggested for the electrodeprocess. Furthermore, the effect of ionic-strength, cations, anions and solvent composition has been studied in terms of the changed electrical double layer