Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the treatment of patients with phenylketonuria (PKU). This enzyme is responsible for the conversion of phenylalanine to trans-cinnamic acid. We assessed the PAL enzyme of the endemic plant Cyathobasis fruticulosa (Bunge) Aellen. for its possible role in the dietary treatment of PKU. The enzyme was found to have a high activity of (64.9±0.1) U/mg, with the optimum pH, temperature and buffer (Tris–HCl and L-phenylalanine) concentration levels of pH=8.8, 37 °C and 100 mM, respectively. Optimum enzyme activity was achieved at pH=4.0 and 7.5, corresponding to pH levels of gastric and intestinal juice, and NaCl concentration of 200 mM. The purifi cation of...
Fenylketonurie je autozomálně recesivní onemocnění, jehož výskyt je 1:10000 novorozenců. Tato práce ...
The presence of an extensive enterorecirculation of amino acids between the intestine and the body, ...
Objective: To review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of a...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Phenylketonuria (PKU) is an inborn error of amino acid metabolism caused by phenylalanine hydroxylas...
Context: Phenylketonuria (PKU) is the most common hereditary defect of phenylalanine hydroxylase (PA...
Fenilketonüri (PKU), fenilalanin hidrosilaz (PAH) geninde mutasyon sebebiyle gelişen otozomal resesi...
Abstract - Phenylketonuria (PKU) is an inherited metabolic disorder caused by mutations in the pheny...
Phenylketonuria (PKU), an autosomal recessive inherited metabolic disorder, is caused by a mutation ...
Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine ...
Phenylketonuria (PKU) and related forms of non-PKU hyperphenylalaninemias (HPA) result from deficien...
Phenylketonuria and hyperphenylalanemia are autosomal recessive inborn errors of phenylalanine metab...
Fenylketonurie je autozomálně recesivní onemocnění, jehož výskyt je 1:10000 novorozenců. Tato práce ...
The presence of an extensive enterorecirculation of amino acids between the intestine and the body, ...
Objective: To review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of a...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Enzyme substitution therapy with the phenylalanine ammonia lyase (PAL) is a new approach to the trea...
Phenylketonuria (PKU) is an inborn error of amino acid metabolism caused by phenylalanine hydroxylas...
Context: Phenylketonuria (PKU) is the most common hereditary defect of phenylalanine hydroxylase (PA...
Fenilketonüri (PKU), fenilalanin hidrosilaz (PAH) geninde mutasyon sebebiyle gelişen otozomal resesi...
Abstract - Phenylketonuria (PKU) is an inherited metabolic disorder caused by mutations in the pheny...
Phenylketonuria (PKU), an autosomal recessive inherited metabolic disorder, is caused by a mutation ...
Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine ...
Phenylketonuria (PKU) and related forms of non-PKU hyperphenylalaninemias (HPA) result from deficien...
Phenylketonuria and hyperphenylalanemia are autosomal recessive inborn errors of phenylalanine metab...
Fenylketonurie je autozomálně recesivní onemocnění, jehož výskyt je 1:10000 novorozenců. Tato práce ...
The presence of an extensive enterorecirculation of amino acids between the intestine and the body, ...
Objective: To review the pharmacology, pharmacokinetics, efficacy, safety, and place in therapy of a...