ETIOLOGY OF PROSTATE CANCER

Za rak prostate može se reći da je jedan od najvažnijih medicinskih problema u muškoj populaciji. U razvoju i progresiji karcinoma prostate bitne su epigenetska regulacija ekspresije gena pomoću promotora metilacije i acetilacije histona, proupalni enzim ciklooksigenaza-2, kao i somatske mutacije različitih gena s različitim biološkim funkcijama.Prostate cancer is now recognized as one of the most important medical problems in male population. Epigenetic regulation of gene expression by promoter methylation and histone acetylation, proinfl ammatory enzyme cyclooxygenase-2 and somatic mutations in a variety of genes with diverse biological functions has been implicated in prostate cancer development and progression