The possibilities of medical therapy in oral lichen ruber

Unatoč tome što se u terapiji oralnog lihena rubera preporučuje niz različitih sredstava terapija je neuspješna. Autori su željeli ispitati djelovanje općih i lokalnih terapijskih postupaka. Ispitivanje je obuhvatilo skupinu od 50 bolesnika s kliničkim manifestacijama oralnog lihena. Na jednoj skupini ispitanika provedena je opća vitaminska terapija uz lokalnu, primjenu kortikosteroida. Druga skupina liječena je kemoterapijskim sredstvima metromdazolom i penicilinom. Dobiveni rezultati pokazuju statistički značajno bržu sanaciju patoloških lezi ja oralne sluznice ispitanika liječenih kemoterapijskim preparatima. Također su remisije lihen rubera na oralnoj sluznici produžene u pacijenata liječenih tim sredstvima.Despite the fact that several therapeutic aaents are recommened to treat lichen ruber, the therapy of this disease is often unsuccessful. An attempt was made to investigate the effects of some general and topical agents used in the treatment of lichen ruber. A total of 50 subjects with clinical manifestations of oral lichen, divided into two subgroups were studied. The patients in the first subgroup were gi¬ven general vitamin therapy and had topical treatment with cortico¬steroids. The other subgroup was treated with the chemotherapeutic agents, metronidazole and penicillin. The results obtained have shown that chemotherapy affords a statistically significantly faster healing of the oral mucosa and that the remissions of lichen ruber on the ora Imucosa last longer in patients treated by these agents